In Arnauld’s view, a fruitful clarification of the nature of knowledge is possible if only one pays close attention to “ce qui se passe en nous,” in such a fashion “de n’y rien mêler dont nous ne soyons certains.” In support of his position, he cites not only Descartes’ testimony but also that of St. Augustine. Consequently, he treats—first of all—of the things that any one can know about his own soul upon consulting with himself with a little attention, and (...) by so doing Arnauld shows once again his faithfulness to the spirit of Cartesianism. Yet he does more, for he is among the first thinkers fully to appreciate the value of a truly descriptive method in philosophy. (shrink)

In the present study of Descartes’ epistemological investigations, I have tried to show that his renowned principle of clarity and distinctness is not, in fact, one but two axioms. Most interpreters and critics have taken the two formulations of such a principle here considered as successive moments of it. At best, this position is insufficient, for each “version” of the principle of clarity and distinctness guarantees different kinds of cognitive content. Moreover, while the validity of one “version” is not dependent (...) on the thesis of God’s veracity, no such thing can be asserted of the validity of the other. These two formulations of the principle of clarity and distinctness are: 1. Whatever is clearly and distinctly perceived is true; 2. whatever we perceive clearly and distinctly as belonging to the nature of something can indeed be predicated of the thing in question. The fust formula corresponds to what I have characterized as “presentative” knowledge; the second one expresses the guarantee of “representative” knowledge. This distinction is all-important for solving the question of whether Descartes’ proofs of God’s existence and veracity---both the a priori and the a posteriori proofs that we find in the Cartesian corpus-are circular. On the basis of such a distinction, it is possible to argue that at least the ontological argument---and possibly as well the proof “par les effets”---is not at all dependent on the principle of clarity and distinctness, which in turn draws its ultimate validity from God’s faithfulness. In other words, as suggested above, only the second “version” needs to be guaranteed by God’s veracity. On the other hand, the first “version” has no normative value, for it merely describes what is the case whenever a clear and distinct cognition occurs. An example of this is our knowledge of God as the most perfect being. (shrink)

In the present study of Descartes’ epistemological investigations, I have tried to show that his renowned principle of clarity and distinctness is not, in fact, one but two axioms. Most interpreters and critics have taken the two formulations of such a principle here considered as successive moments of it. At best, this position is insufficient, for each “version” of the principle of clarity and distinctness guarantees different kinds of cognitive content. Moreover, while the validity of one “version” is not dependent (...) on the thesis of God’s veracity, no such thing can be asserted of the validity of the other. These two formulations of the principle of clarity and distinctness are: 1. Whatever is clearly and distinctly perceived is true; 2. whatever we perceive clearly and distinctly as belonging to the nature of something can indeed be predicated of the thing in question. The fust formula corresponds to what I have characterized as “presentative” knowledge; the second one expresses the guarantee of “representative” knowledge. This distinction is all-important for solving the question of whether Descartes’ proofs of God’s existence and veracity---both the a priori and the a posteriori proofs that we find in the Cartesian corpus-are circular. On the basis of such a distinction, it is possible to argue that at least the ontological argument---and possibly as well the proof “par les effets”---is not at all dependent on the principle of clarity and distinctness, which in turn draws its ultimate validity from God’s faithfulness. In other words, as suggested above, only the second “version” needs to be guaranteed by God’s veracity. On the other hand, the first “version” has no normative value, for it merely describes what is the case whenever a clear and distinct cognition occurs. An example of this is our knowledge of God as the most perfect being. (shrink)

Rho proteins belong to the small GTPases superfamily. They function as molecular switches that, in response to diverse stimuli, control key signaling and structural aspects of the cell. Although early studies proposed a role for Rho GTPases in cellular transformation, this effect was underestimated due to the fact that no genetic mutations affecting Rho‐encoding genes were found in tumors. Recently, it has become evident that Rho GTPases participate in the carcinogenic process by either overexpression of some of the members of (...) the family with oncogenic activity, downmodulation of other members with suggested tumor suppressor activity, or by alteration of upstream modulators or downstream effectors. Thus, alteration of the levels of expression of different members of the family of Rho GTPases has been detected in many types of human tumors leading to a great interest in the cellular effects elicited by these oncoproteins. This essay reviews the current evidence of dysregulation of Rho signaling by overexpression in human tumors. BioEssays 27:602–613, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Studies have shown that as MRI T2 relaxation time lengthens there is a shift toward more unbound or “free-water” and less partitioning of the protein/lipid molecules per unit volume. A shift toward less water partitioning or lengthened MRI T2 relaxation time is linearly related to reduced high frequency EEG amplitude, reduced short distance EEG coherence, increased long distance EEG coherence, and reduced cognitive functioning (Thatcher et al. 1998a; 1998b).

When men and women cannot attain idealized gendered forms of economic provision and dependence, how do they make sense of this perceived failure? In this article, we posit that poor health narratives serve as a gendered tool to make sense of inadequate livelihoods, even when that inadequacy is attributable to structural conditions. We draw on survey and life-history interview data from middle-aged and older rural South Africans. The survey data show that even after adjusting for biometrically measured health differences, working-age (...) men report poorer health when they are unemployed, and women and pension-age men report poorer health when they live without household earners. Life-history interviews show parallel patterns: When their economic circumstance is not troubled, individuals regularly minimize health concerns; conversely, when they have a troubled livelihood, individuals draw on poor health to explain it. When women and men cannot perform idealized gendered practices in the family, poor health becomes a tool to reduce the resulting cognitive dissonance. Poor health narratives recast perceived gender failures to an individualized, biological explanation. Our study illustrates how the epidemiological context can be a resource that forestalls a redefinition of gender norms when the gender order is in crisis. (shrink)

The ability of the medical profession to sustain life, or more appropriately, to prolong dying, in patients with terminal illness, creates a most complex and controversial situation for all involved: the patient, if mentally alert; the patient's family; and the medical care team including physicians, nurses and attendants. This situation is especially complex in large acute care hospitals where medical and nursing students, residents and house officers receive advanced medical training. A major problem, prolonging the dying of the terminally ill, (...) with its medical, legal, ethical and economic complexities now confronts American society. The problem is particularly acute in teaching hospitals, in which one finds a disproportionate number of terminally ill patients. The ability to work at these questions as a community rather than as adversaries will determine much about the ability of the health care system to respect the dignity and autonomy of those who seek aid and comfort when faced with serious illness and impending death. Better communication between the physicians, health care providers, the lawyers and ethicists must be developed in order to solve these problems. Over the next ten years society and our elected representatives will be making very demanding decisions about the use of the health dollar. One possible way to prevent increasing costs is to reach significant agreement on the proper care of the dying. Proper care for the dying is being considered, discussed, and evaluated by very thoughtful people. It is not governments which should decide who is to live or who is to die. There is the serious problem of the 'slippery slope' to euthanasia by omission if cost containment becomes the major force in formulating policy on the proper care of the dying. (shrink)

This article analyzes the relation of the epistemological beliefs of students and teachers and the actions deployed in the classroom. The framework is the study of personal epistemology, which was developed, among other researchers, by Hofer, Pintrich and Schommer. The research method was, within the qualitative paradigm, through case studies, given the interest in describing the phenomenon in a specific scenario. The results show the epistemological beliefs of teachers and students, the events that make them evident and its relationship with (...) the behaviors shown in the classroom. The role of pedagogical beliefs as mediation between personal epistemology of educational actors and their practice are described and, finally, the relation between beliefs and educational practice is illustrated by analyzing specific class events and the justification expressed by teachers and students about their actions in the classroom. (shrink)

We revise the mathematical implementation of the Dirac formulation of quantum mechanics, presenting a rigorous framework that unifies most of versions of this implementation.

According to kin selection theory, indirect reproductive advantages may induce individuals to care for others with whom they share genes by common descent, and the amount of care, including self-sacrifice, will increase with the proportion of genes shared. Twins represent a natural situation in which this hypothesis can be tested. Twin pairs experience the same early environment because they were born and raised at the same time and in the same family but their genetic relatedness differs depending on zygosity. We (...) compared the degree of willingness to fight and sacrifice for the co-twin among monozygotic and dizygotic pairs in a sample of 1443 same-sex and opposite-sex twins. We also analyzed the effect of the subject’s gender and that of the co-twin on those altruistic behaviors. Results partly supported the postulated explanation. MZ twins were significantly more likely than DZ twins to self-sacrifice for their co-twins, but zygosity did not affect willingness to fight for him/her. The genders of the subject and of the co-twin, not genetic relatedness, were the best predictors of aggressive altruistic intentions. (shrink)

According to kin selection theory, indirect reproductive advantages may induce individuals to care for others with whom they share genes by common descent, and the amount of care, including self-sacrifice, will increase with the proportion of genes shared. Twins represent a natural situation in which this hypothesis can be tested. Twin pairs experience the same early environment because they were born and raised at the same time and in the same family but their genetic relatedness differs depending on zygosity. We (...) compared the degree of willingness to fight and sacrifice for the co-twin among monozygotic and dizygotic pairs in a sample of 1443 same-sex and opposite-sex twins. We also analyzed the effect of the subject’s gender and that of the co-twin on those altruistic behaviors. Results partly supported the postulated explanation. MZ twins were significantly more likely than DZ twins to self-sacrifice for their co-twins, but zygosity did not affect willingness to fight for him/her. The genders of the subject and of the co-twin, not genetic relatedness, were the best predictors of aggressive altruistic intentions. (shrink)

In this article we examine the way in which the American Alt-Right movement has made Friedrich Nietzsche its most influential philosopher. The authors ascribed to the Alt-Right evidence a strong liking for the German philosopher's ideas, which resonate forcefully in many their principal policies: specifically, the characterisation of our contemporaneity as “decadent”, the comparison between “superior men” and the project to construct a “white ethnostate”, and the advocacy of Christianity, as opposed to Christianism, as an identity structure for defining white (...) civilisation. Having trawled the main Alt-Right forums of ideological expression and analysed the key writings of their theorists, references and spokespersons, we aim to present a systematic explanation of how this advocacy has been built on certain Nietzschean themes. We also argue that this is a partial, superficial and contradictory reading of Nietzsche, as well as a narrow and distorted interpretation. (shrink)

Los convulsos acontecimientos de estos últimos años han demostrado, a escala global, cuán enajenante es nuestra experiencia presente del tiempo. Las tendencias actuales de la teoría crítica y otros enfoques histórico-sociológicos insisten en el ritmo devorador de la aceleración (P. Virilio; H. Rosa) y en la reconfiguración temporal a partir del “presentismo” (Koselleck; F. Hartog). Sin embargo, sabemos que estas cuestiones distan de ser absolutamente nuevas, y que ya preocupaban a los filósofos y a los fenomenólogos en la primera mitad (...) del siglo XX. La publicación reciente de los últimos tratados del Ereignis y de los Cuadernos negros, redactados en los años 1930 y 1940, nos permite acceder a una reflexión original sobre lo que Heidegger nombra la maquinación o fabricación [Machenschaft]. Nos gustaría analizar la manera en la que, a partir de la fabricación, se puede replantear el sentido de nuestra experiencia temporal íntima frente a la situación moderna. Más concretamente, ahondaremos en las formas en las que la primacía de la fabricación funciona como cerrazón de posibilidades, llegando a impedir que pueda ocurrir algo realmente “histórico”. (shrink)

Se plantean los problemas y algunas temáticas características de la "independencia literaria" en Hispanoamérica, a la luz de la coyuntura de la emancipación política de España. Este tema desborda los marcos temporales o la periodización de las guerras de independencia; recorre todo el siglo XIX y pa..

This article discusses some of the characteristic problems and issues of the so-called “literary independence” of Spanish America in the light of its political emancipation from Spain. This topic goes beyond the temporal framework or the periodization of the wars of independence; instead, it covers the entire nineteenth century and part of the twentieth, and appears discontinuously and non-simultaneously in the different nations. The path followed by Spanish American literature was filled with vicissitudes,manifestations, and regressions of diverse types. The paper (...) specifically analyzes La biblioteca americana and El repertorio americano by the Venezuelan, Andrés Bello, and Juan García del Río, a native of Cartagena, as well as the role of the young Argentinean Domingo F. Sarmiento, author of Facundo, in the genesis and first outlines of an independent Spanish American “literary expression”. (shrink)

: This paper starts from three assumptions: that we are essentially human organisms, that we start to exist at conception, and that we retain our identity throughout our lives. The identity claim provides the background to argue that it is irrational for a person to claim that it would be impermissible to kill her now but permissible to have killed her at an earlier age. The notion of "full moral status" as an ascertainable property is questioned and shown to be (...) dependent on previously accepted moral norms. It is concluded that the exclusion of the very young from the scope of the norm o f common morality that prohibits the killing of the innocent amounts to discrimination on the basis of age. (shrink)

Muchos problemas deliberativos son multidimensionales: los argumentos a favor y en contra de las soluciones propuestas apelan a valores que pertenecen a distintas dimensiones. Así, por ejemplo, los argumentos a favor de la propuesta de negociar para resolver el problema de un conflicto armado interno pueden apelar a la paz mientras que los argumentos en contra pueden apelar a la justicia. Esto hace posible que los interlocutores acepten las premisas de un argumento sin comprometerse con su conclusión y que lo (...) justifiquen haciendo énfasis en las premisas del argumento contrario – “sí, una negociación reduciría el número de los muertos por violencia política, pero generaría impunidad, así que no debemos negociar”-. Si esta situación fuera insuperable, los argumentos en la deliberación nunca podrían ser válidos, nunca podrían ser tales que la aceptación de las premisas comprometiera a quien las acepta con las conclusiones. En este artículo considero algunas respuestas a este problema: las respuestas de C. Kock, T. Govier, P. Olmos y la respuesta de F. Macagno y D. Walton; señalo algunos problemas que encuentro en estas respuestas e intento resolverlos distinguiendo los casos en que es posible de los casos en los que no es posible superar el problema de la multidimensionalidad en la deliberación. (shrink)

Sartre's Critique of theUniversal: Elements for a Multicultural Thinking The question of cultural justice, which refers in different contexts to the exigency of universality, constitutes a central aspect of Sartre's writings after World War II as f. ex. Réflexions sur la question juive, Orphée noir, Cahiers pour une morale, the famous Preface to Les damnés de la terre of Franz Fanon, and his article on the "question basque". In this texts Sartre poses some questions, which are crucial for the contemporary (...) multiculturalism debates, specially the questions of cultural justice, of the concepts of universality and the practical subject, of the articulation between cultural justice and distributive justice, as well as of the relation between person, economics and culture. The aims of this article is to discuss the main points of Sartre's critique of the abstract universality on the basis of his Réflexions sur la question juive, and to articulate the fields where Sartre's thought offers the theoretical resources for a contemporary debate on cultural justice. (shrink)

Se trata de una breve reseña del volumen colectivo editado por Fina Birulés, Antonio Gómez Ramos y Concha Roldán (eds.), Vivir para pensar. Ensayos en homenaje a Manuel Cruz , Herder, Barcelona, 2012, 458 p. En este volumen participan veintisiete autores españoles y de otros países europeos, iberoamericanos y de habla inglesa.

This landmark work provides a systematic introduction to systems of modal logic and stands as the first presentation of what have become central ideas in philosophy of language and metaphysics, from the "new theory of reference" and non-linguistic necessity and essentialism to "Kripke semantics.".

Resumen: En este artículo se hará, en primer lugar, una breve revisión de las diferentes interpretaciones del escepticismo de Michel de Montaigne; en segundo lugar, una tentativa de unificación de dichas interpretaciones -utilizando la del profesor F. Brahami como referente heurístico- a partir de los rasgos más generales presentes en el escepticismo del bordolés; y, en tercer lugar, se identificarán estos rasgos en la obra Notas de Nicolás Gómez Dávila, que para los autores es un texto escéptico de corte montaigniano.: (...) In this article we will do, in the first place, a brief review of the different interpretations on Michel de Montaigne's skepticism. In the second place, we will try to unify these interpretations -with the one of Professor Brahami as heuristic reference-, considering the more general traits of his skepticism. Thirdly, we will try to identify these traits in the work Notas of Nicolás Gómez Dávila that, in our opinion, is a skeptical montaignian text. (shrink)

Mirativity is a grammatical category or a linguistic strategy that makes explicit the surprising aspect of a piece of information. Different mirativity strategies appear in different languages. Evidentiality is a grammatical category that explicitly expresses the source of information, i.e. if something has been seen, heard or inferred. Whether mirativity forms part of evidentiality is an open question. An agent makes use of a mirativity marker when she or he expresses something about a surprising fact with respect to her or (...) his background knowledge. But there are different kinds of mirativity markers. Some of them are simple and direct and others, more complex, involve inferential processes. Here, we focus on complex mirativity and we compare it with inferred evidentials and deferred realizations. Our proposal goes beyond the purely linguistic analysis, since we try to interpret mirativity, and its role in interaction, as forming part of or involving a particular kind of inference, namely abduction. Mirativity can be used to express the surprising state that triggers an abductive reasoning but it can also encapsulate its result in such a way that it can be understood in relation to evidentiality. Thus, at least in some cases of complex mirativity, mirativity may convey indication about the source of information. Interesting for studies on dialogue is that they also indicate the degree of commitment of the speakers with the content of their own utterances. (shrink)

Ciencias sociales : saberes coloniales y eurocéntricos / Edgardo Lander / - Europa modernidad y eurocentrismo / Enrique Dussel / - La colonialidad a lo largo y a lo ancho : el hemisferio occidental en el horizonte colonial de la modernidad / Walter D. Mignolo / - Naturaleza del poscolonialismo : del eurocentrismo al globocentrismo / Fernando Coronil / - El lugar de la naturaleza y la naturaleza del lugar : ¿globalización o postdesarrollo? / Arturo Escobar / - Ciencias sociales, (...) violencia epistémica y el problema de la invención del otro / Santiago Castro-Gómez / - Superar la exclusión, conquistar la equidad : reformas, políticas y capacidades en el ámbito social / Alejandro Moreno / - Abrir, impensar, y redimesionar las ciencias sociales en América Latina y el Caribe. ¿Es posible una ciencia social no eurocéntrica en nuestra región? / Francisco López Segrera / - Colonialidad del poder, eurocentrismo y América Latina / Aníbal Quijano. (shrink)

Quadruple Helix Collaborations (QHCs) is a cooperation model in which industry, government, academia, and the public interact to innovate. This paper analyses the impact of a training intervention to provide specific knowledge, skills, and attitudes to deal with barriers commonly found in the progress of QHCs. We designed, implemented, and evaluated three training programs in Austrian, Colombian, Danish, and Spanish institutions. We analysed trainees’ (n = 66) and trainers’ (n = 9) perceptions to identify the competencies acquired with the intervention (...) and the approach’s limitations. We used online questionnaires (35 trainees; 9 trainers), semi-structured interviews (10 trainees), and a focus group (6 trainers). Trainees answered positively regarding their self-perception about the impact of the course and highlighted the acquisition of inspiration for their practice (score 4.1 out of 5.0) and knowledge (3.7). In contrast, they perceived that a deeper interaction with other participants (2.7) was challenging. After the courses, 74% of respondents indicated that they know more about how QHCs work in practice, and 86% about collaboration or engagement methods. Moreover, participants plan to be more sensitive towards setting common goals (71%) and power imbalances (63%). Trainers’ perceptions align with those expressed by participants, except that they considered that the interaction amongst participants during the course was higher. Qualitative analysis of interviews with participants and the focus group with trainers provides more detail about the strengths and weaknesses of the intervention. Our study shows that the collaborative design and implementation of training impact the participant’s learning competencies, with potential implications in their medium- to long-term practice. (shrink)